Reaction Details Report a problem with these data
Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM50350281
Substrate
n/a
Meas. Tech.
ChEMBL_825690 (CHEMBL2044107)
Ki
21000±n/a nM
Citation
 Moineaux, L; Laurent, S; Reniers, J; Dolušic, E; Galleni, M; Frère, JM; Masereel, B; Frédérick, R; Wouters, J Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles. Eur J Med Chem 54:95-102 (2012) [PubMed]  Article 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47874.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_825691
Residue:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
  
Inhibitor
Name:
BDBM50350281
Synonyms:
CHEMBL1812527
Type:
Small organic molecule
Emp. Form.:
C15H11ClN2
Mol. Mass.:
254.714
SMILES:
Clc1cccc2c(\C=C\c3cccnc3)c[nH]c12
Structure:
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