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Target
Pyroglutamylated RF-amide peptide receptor
Ligand
BDBM50396427
Substrate
n/a
Meas. Tech.
ChEMBL_862135 (CHEMBL2174320)
EC50
1095±n/a nM
Citation
 Neveu, C; Lefranc, B; Tasseau, O; Do-Rego, JC; Bourmaud, A; Chan, P; Bauchat, P; Le Marec, O; Chuquet, J; Guilhaudis, L; Boutin, JA; Ségalas-Milazzo, I; Costentin, J; Vaudry, H; Baudy-Floc'h, M; Vaudry, D; Leprince, J Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-ß3-pseudopeptide agonist. J Med Chem 55:7516-24 (2012) [PubMed]  Article 
Target
Name:
Pyroglutamylated RF-amide peptide receptor
Synonyms:
GPR103 | Pyroglutamylated RFamide peptide receptor | QRFPR | QRFPR_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49508.46
Organism:
Homo sapiens (Human)
Description:
GPR103 0 HUMAN::Q96P65
Residue:
431
Sequence:
MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
  
Inhibitor
Name:
BDBM50396427
Synonyms:
CHEMBL2170397
Type:
Small organic molecule
Emp. Form.:
C40H54N12O7
Mol. Mass.:
814.933
SMILES:
[#6]-[#7](-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7] |r|
Structure:
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