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Target
Methylated-DNA--protein-cysteine methyltransferase
Ligand
BDBM5491
Substrate
n/a
Meas. Tech.
ChEMBL_863278 (CHEMBL2176221)
IC50
39±n/a nM
Citation
 Zhu, R; Seow, HA; Baumann, RP; Ishiguro, K; Penketh, PG; Shyam, K; Sartorelli, AC Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase. Bioorg Med Chem Lett 22:6242-7 (2012) [PubMed]  Article 
Target
Name:
Methylated-DNA--protein-cysteine methyltransferase
Synonyms:
6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN
Type:
PROTEIN
Mol. Mass.:
21651.27
Organism:
Homo sapiens (Human)
Description:
ChEMBL_144711
Residue:
207
Sequence:
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPGLGGSSGLAGAWLKGAGATSGSPPAGRN
  
Inhibitor
Name:
BDBM5491
Synonyms:
6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6-Substituted Guanine Deriv. 31
Type:
Small organic molecule
Emp. Form.:
C12H11N5O
Mol. Mass.:
241.2486
SMILES:
Nc1nc(OCc2ccccc2)c2[nH]cnc2n1
Structure:
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