Reaction Details Report a problem with these data
Target
TGF-beta receptor type-2
Ligand
BDBM50399843
Substrate
n/a
Meas. Tech.
ChEMBL_877385 (CHEMBL2182430)
IC50
760±n/a nM
Citation
 Schade, D; Lanier, M; Willems, E; Okolotowicz, K; Bushway, P; Wahlquist, C; Gilley, C; Mercola, M; Cashman, JR Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFß signaling. J Med Chem 55:9946-57 (2012) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-2
Synonyms:
TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
64559.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586859
Residue:
567
Sequence:
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
  
Inhibitor
Name:
BDBM50399843
Synonyms:
CHEMBL2180280
Type:
Small organic molecule
Emp. Form.:
C27H26F3NO3
Mol. Mass.:
469.4954
SMILES:
CC1=C(C(C2C(=O)CC(C)(C)CC2=N1)c1ccc(cc1)-c1ccccc1)C(=O)OCC(F)(F)F |c:13,t:1|
Structure:
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