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Target
Glutaminase liver isoform, mitochondrial
Ligand
BDBM108460
Substrate
n/a
Meas. Tech.
ChEMBL_877992 (CHEMBL2189058)
IC50
5500±n/a nM
Citation
 Shukla, K; Ferraris, DV; Thomas, AG; Stathis, M; Duvall, B; Delahanty, G; Alt, J; Rais, R; Rojas, C; Gao, P; Xiang, Y; Dang, CV; Slusher, BS; Tsukamoto, T Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J Med Chem 55:10551-63 (2012) [PubMed]  Article 
Target
Name:
Glutaminase liver isoform, mitochondrial
Synonyms:
GLS | GLSL_MOUSE | Gls2 | Kiaa4146 | L-glutaminase | L-glutamine amidohydrolase
Type:
PROTEIN
Mol. Mass.:
66377.32
Organism:
Mus musculus
Description:
ChEMBL_877992
Residue:
602
Sequence:
MRSMRALQNALSRAGSHGRRGGWGHPSRGPLLGRGVRYYLGEAAAQGRGTPHSHQPQHSDHDASHSGMLPRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLQDCMSKMQRMVQESSSGGLLDRELFQKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDAKEPTGGKVAAYIPHLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISVSTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEFMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSQRGINFCQKLVSLFNFHNYDNLRHCARKLDPRREGGEVRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFVKDRWGNIPLDDAVQFNHLEVVKLLQDYHDSYLLSETQAEAAAETLSKENLESMV
  
Inhibitor
Name:
BDBM108460
Synonyms:
CHEMBL2178393 | US11191732, Example 1 | US8604016, 17 | US9938267, Cmpd ID 17
Type:
Small organic molecule
Emp. Form.:
C16H18N6OS3
Mol. Mass.:
406.549
SMILES:
Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1
Structure:
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