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Found 116 with Last Name = 'stathis' and Initial = 'm'
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50246899((S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM108460(CHEMBL2178393 | US11191732, Example 1 | US8604016,...)
Affinity DataKi:  2.00E+3nMAssay Description:Uncompetitive inhibition of human kidney glutaminase (124 to 669) assessed as reduction of glutamine hydrolysis by double-reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392040(CHEMBL2152556)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392045(CHEMBL2152561)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392046(CHEMBL2152562)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17775(3-(1-carboxy-4-sulfanylbutoxy)benzoic acid | Thiol...)
Affinity DataIC50:  14nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17762(3-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Affinity DataIC50:  15nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM17762(3-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Affinity DataIC50:  15nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM17762(3-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392041(CHEMBL2152557)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332228(1-(3-Carboxyphenyl)-3-(2-mercapto-ethyl)-1H-indole...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332217(1-[(2-carboxyphenyl)methyl]-3-(2-mercaptoethyl)-1H...)
Affinity DataIC50:  22nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332218(1-[(3-carboxyphenyl)methyl]-3-(2-mercaptoethyl)-1H...)
Affinity DataIC50:  22nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332228(1-(3-Carboxyphenyl)-3-(2-mercapto-ethyl)-1H-indole...)
Affinity DataIC50:  22nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17776(3-[(1-carboxy-4-sulfanylbutyl)sulfanyl]benzoic aci...)
Affinity DataIC50:  32nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332221(1-[[3-carboxy-5-(1,1-dimethylethyl)phenyl]methyl]-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392036(CHEMBL2152437)
Affinity DataIC50:  38nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392039(CHEMBL2152555)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392037(CHEMBL2152438)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332220(1-[(2-bromo-5-carboxyphenyl)methyl]-3-(2-mercaptoe...)
Affinity DataIC50:  54nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17763(4-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Affinity DataIC50:  63nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392049(CHEMBL2152565)
Affinity DataIC50:  69nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM108730(US8604016, 375 | US9938267, Cmpd ID 309)
Affinity DataIC50:  70nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50178230(CHEMBL3814265 | US11191732, Example 5)
Affinity DataIC50:  70nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM108731(US8604016, 310 | US9938267, Cmpd ID 310)
Affinity DataIC50:  70nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17752(2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...)
Affinity DataIC50:  82nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM17755(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM17755(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Affinity DataIC50:  90nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17755(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Affinity DataIC50:  90nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332223(1-[(2-carboxy-5-methoxyphenyl)methyl]-3-(2-mercapt...)
Affinity DataIC50:  93nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332219(1-[(4-carboxyphenyl)methyl]-3-(2-mercaptoethyl)-1H...)
Affinity DataIC50:  94nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50178229(CHEMBL3814401)
Affinity DataIC50:  110nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17777(3-[2-carboxy-2-(phosphonomethyl)ethyl]benzoic acid...)
Affinity DataIC50:  120nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50178224(CHEMBL3814214)
Affinity DataIC50:  120nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50178226(CHEMBL3813967)
Affinity DataIC50:  120nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50178235(CHEMBL3814231)
Affinity DataIC50:  120nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50178222(CHEMBL3814899)
Affinity DataIC50:  140nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332222(1-[(4-bromo-3-carboxyphenyl)methyl]-3-(2-mercaptoe...)
Affinity DataIC50:  140nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392048(CHEMBL2152564)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50178234(CHEMBL3814007)
Affinity DataIC50:  170nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17767(3-[2-carboxy-2-(5-sulfanylpentyl)ethyl]benzoic aci...)
Affinity DataIC50:  190nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392050(CHEMBL2152566)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392047(CHEMBL2152563)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50178260(CHEMBL3813769)
Affinity DataIC50:  210nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Mgi Pharma

LigandPNGBDBM17779(2-[(hydroxycarbamoyl)methyl]pentanedioic acid | CH...)
Affinity DataIC50:  220nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392044(CHEMBL2152560)
Affinity DataIC50:  230nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392035(CHEMBL2152436)
Affinity DataIC50:  340nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50178259(CHEMBL3813734)
Affinity DataIC50:  380nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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