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Target
C-C chemokine receptor type 1
Ligand
BDBM50402807
Substrate
n/a
Meas. Tech.
ChEMBL_887246 (CHEMBL2215802)
Ki
15.85±n/a nM
Citation
 Furber, M; Alcaraz, L; Luckhurst, C; Bahl, A; Beaton, H; Bowers, K; Collington, J; Denton, R; Donald, D; Kinchin, E; MacDonald, C; Rigby, A; Riley, R; Soars, M; Springthorpe, B; Webborn, P Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I. Bioorg Med Chem Lett 22:7702-6 (2012) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50402807
Synonyms:
CHEMBL2208416
Type:
Small organic molecule
Emp. Form.:
C25H30Cl2N2O4
Mol. Mass.:
493.423
SMILES:
OC(COc1ccccc1NC(=O)C1CCC1)CN1CCC(CC1)Oc1ccc(Cl)c(Cl)c1
Structure:
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