Reaction Details Report a problem with these data
Target
ATP synthase subunit gamma, mitochondrial
Ligand
BDBM50062397
Substrate
n/a
Meas. Tech.
ChEMBL_65923 (CHEMBL678318)
IC50
>100000±n/a nM
Citation
 Atwal, KS; Wang, P; Rogers, WL; Sleph, P; Monshizadegan, H; Ferrara, FN; Traeger, S; Green, DW; Grover, GJ Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors. J Med Chem 47:1081-4 (2004) [PubMed]  Article 
Target
Name:
ATP synthase subunit gamma, mitochondrial
Synonyms:
ATP5C | ATP5C1 | ATP5F1C | ATPG_BOVIN | F-ATPase gamma subunit
Type:
PROTEIN
Mol. Mass.:
33081.70
Organism:
Bos taurus
Description:
ChEMBL_65923
Residue:
298
Sequence:
MFSRAGVAGLSAWTVQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARVYGVGSLALYEKADIKTPEDKKKHLIIGVSSDRGLCGAIHSSVAKQMKSEAANLAAAGKEVKIIGVGDKIRSILHRTHSDQFLVTFKEVGRRPPTFGDASVIALELLNSGYEFDEGSIIFNRFRSVISYKTEEKPIFSLDTISSAESMSIYDDIDADVLRNYQEYSLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
  
Inhibitor
Name:
BDBM50062397
Synonyms:
3N-cyanoimino(tert-pentylamino)methyl-3-pyridinamine | 3N-cyanoimino(tert-pentylamino)methyl-3-pyridinamineP1075) | CHEMBL11458 | N''-cyano-N-(1,1-dimethylpropyl)-N'-pyridin-3-ylguanidine | N-cyano-N''-(1,1-dimethylpropyl)-N'-pyridin-3-ylguanidine | P-1075
Type:
Small organic molecule
Emp. Form.:
C12H17N5
Mol. Mass.:
231.2969
SMILES:
CCC(C)(C)NC(NC#N)=Nc1cccnc1 |w:10.10|
Structure:
Search PDB for entries with ligand similarity: