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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM50416511
Substrate
n/a
Meas. Tech.
ChEMBL_647126 (CHEMBL1217267)
IC50
>100000±n/a nM
Citation
 Solorzano, C; Antonietti, F; Duranti, A; Tontini, A; Rivara, S; Lodola, A; Vacondio, F; Tarzia, G; Piomelli, D; Mor, M Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. J Med Chem 53:5770-81 (2010) [PubMed]  Article 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa
Type:
Enzyme
Mol. Mass.:
40306.53
Organism:
Rattus norvegicus (Rat)
Description:
Q5KTC7
Residue:
362
Sequence:
MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHYDPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVLVNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFVGYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVYTLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVPKRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRNPS
  
Inhibitor
Name:
BDBM50416511
Synonyms:
CHEMBL1214258 | US9321743, URB827
Type:
Small organic molecule
Emp. Form.:
C12H15NO4
Mol. Mass.:
237.2518
SMILES:
OC[C@H](NC(=O)CCc1ccccc1)C(O)=O |r|
Structure:
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