Reaction Details Report a problem with these data
Target
DNA repair protein RAD51 homolog 1
Ligand
BDBM39129
Substrate
n/a
Meas. Tech.
ChEMBL_937387 (CHEMBL2319671)
IC50
19700±n/a nM
Citation
 Budke, B; Kalin, JH; Pawlowski, M; Zelivianskaia, AS; Wu, M; Kozikowski, AP; Connell, PP An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity. J Med Chem 56:254-63 (2013) [PubMed]  Article 
Target
Name:
DNA repair protein RAD51 homolog 1
Synonyms:
RAD51 | RAD51A | RAD51_HUMAN | RECA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36960.74
Organism:
Homo sapiens (Human)
Description:
gi_49168602
Residue:
339
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
  
Inhibitor
Name:
BDBM39129
Synonyms:
3-chloranyl-1-(2-chlorophenyl)-4-morpholin-4-yl-pyrrole-2,5-dione | 3-chloro-1-(2-chlorophenyl)-4-(4-morpholinyl)pyrrole-2,5-dione | 3-chloro-1-(2-chlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione | 3-chloro-1-(2-chlorophenyl)-4-morpholino-3-pyrroline-2,5-quinone | MLS-0013275.0001 | cid_796318
Type:
Small organic molecule
Emp. Form.:
C14H12Cl2N2O3
Mol. Mass.:
327.163
SMILES:
ClC1=C(N2CCOCC2)C(=O)N(C1=O)c1ccccc1Cl |c:1|
Structure:
Search PDB for entries with ligand similarity: