Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM26113
Substrate
n/a
Meas. Tech.
ChEMBL_934089 (CHEMBL2318591)
IC50
2000±n/a nM
Citation
 Leung, IK; Demetriades, M; Hardy, AP; Lejeune, C; Smart, TJ; Szöllössi, A; Kawamura, A; Schofield, CJ; Claridge, TD Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. J Med Chem 56:547-55 (2013) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM26113
Synonyms:
2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | pyridine-2,4-dicarboxylic acid
Type:
Small organic molecule
Emp. Form.:
C7H5NO4
Mol. Mass.:
167.1189
SMILES:
OC(=O)c1ccnc(c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: