Reaction Details Report a problem with these data
Target
A disintegrin and metalloproteinase with thrombospondin motifs 5
Ligand
BDBM50431947
Substrate
n/a
Meas. Tech.
ChEMBL_953666 (CHEMBL2352570)
IC50
22000±n/a nM
Citation
 Atobe, M; Maekawara, N; Ishiguro, N; Sogame, S; Suenaga, Y; Kawanishi, M; Suzuki, H; Jinno, N; Tanaka, E; Miyoshi, S A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors. Bioorg Med Chem Lett 23:2106-10 (2013) [PubMed]  Article 
Target
Name:
A disintegrin and metalloproteinase with thrombospondin motifs 5
Synonyms:
ADAMTS5 | ATS5_BOVIN
Type:
PROTEIN
Mol. Mass.:
22582.90
Organism:
Bos taurus
Description:
ChEMBL_953666
Residue:
207
Sequence:
HAAFTVAHEIGHLLGLSHDDSKFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQIPGPEELPGQTYDASQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPKNNGRYCTGK
  
Inhibitor
Name:
BDBM50431947
Synonyms:
CHEMBL2348091
Type:
Small organic molecule
Emp. Form.:
C15H13N3O3S2
Mol. Mass.:
347.412
SMILES:
OC(=O)CCc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccn1
Structure:
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