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Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50327696
Substrate
n/a
Meas. Tech.
ChEMBL_956034 (CHEMBL2380129)
IC50
1900±n/a nM
Citation
 Ramanujulu, PM; Yang, T; Yap, SQ; Wong, FC; Casey, PJ; Wang, M; Go, ML Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem 63:378-86 (2013) [PubMed]  Article 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM50327696
Synonyms:
2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide | CHEMBL240860 | Cysmethynil
Type:
Small organic molecule
Emp. Form.:
C25H32N2O
Mol. Mass.:
376.5344
SMILES:
CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1cccc(C)c1
Structure:
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