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Target
NF-kappa-B inhibitor alpha
Ligand
BDBM50437339
Substrate
n/a
Meas. Tech.
ChEMBL_972404 (CHEMBL2412579)
IC50
>50000±n/a nM
Citation
 Ozawa, M; Morita, M; Hirai, G; Tamura, S; Kawai, M; Tsuchiya, A; Oonuma, K; Maruoka, K; Sodeoka, M Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-kB Activation ACS Med Chem Lett 4:730-5 (2013) [PubMed]  Article 
Target
Name:
NF-kappa-B inhibitor alpha
Synonyms:
I-kappa-B-alpha | IKBA | IKBA_HUMAN | MAD3 | NF-kappa-B inhibitor alpha | NFKBI | NFKBIA
Type:
GST fusion protein
Mol. Mass.:
35584.84
Organism:
Homo sapiens (Human)
Description:
It was produced in E. coli as GST-tagged fusion protein (Santa Cruz Biotechnology).
Residue:
317
Sequence:
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL
  
Inhibitor
Name:
BDBM50437339
Synonyms:
CHEMBL2408039
Type:
Small organic molecule
Emp. Form.:
C28H40O7
Mol. Mass.:
488.613
SMILES:
C[C@@H]1[C@H](C[C@@H](O)[C@](C)(O)[C@@]2(O)CC[C@@]3(O)[C@@H]4CC=C5CC=CC(=O)[C@]5(C)[C@H]4CC[C@]23C)COC1=O |r,c:20,t:17|
Structure:
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