Reaction Details Report a problem with these data
Target
Casein kinase I isoform delta
Ligand
BDBM50439431
Substrate
n/a
Meas. Tech.
ChEMBL_977605 (CHEMBL2423572)
IC50
90±n/a nM
Citation
 Mente, S; Arnold, E; Butler, T; Chakrapani, S; Chandrasekaran, R; Cherry, K; DiRico, K; Doran, A; Fisher, K; Galatsis, P; Green, M; Hayward, M; Humphrey, J; Knafels, J; Li, J; Liu, S; Marconi, M; McDonald, S; Ohren, J; Paradis, V; Sneed, B; Walton, K; Wager, T Ligand-protein interactions of selective casein kinase 1d inhibitors. J Med Chem 56:6819-28 (2013) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50439431
Synonyms:
CHEMBL2420704
Type:
Small organic molecule
Emp. Form.:
C19H19FN4O
Mol. Mass.:
338.3788
SMILES:
Cn1cc(c(n1)-c1ccc(F)cc1)-c1ccnc(c1)C1COCCN1
Structure:
Search PDB for entries with ligand similarity: