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Target
Dihydrofolate reductase
Ligand
BDBM50448354
Substrate
n/a
Meas. Tech.
ChEMBL_1294109 (CHEMBL3122687)
Ki
4000±n/a nM
Citation
 Piras, S; Carta, A; Briguglio, I; Corona, P; Paglietti, G; Luciani, R; Costi, MP; Ferrari, S 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes. Eur J Med Chem 75:169-83 (2014) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50448354
Synonyms:
CHEMBL3121443
Type:
Small organic molecule
Emp. Form.:
C26H24F3N3O2
Mol. Mass.:
467.4829
SMILES:
CCN(Cc1nc2cc(ccc2nc1-c1ccccc1)C(F)(F)F)c1ccc(OC)c(OC)c1
Structure:
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