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Target
Integrase
Ligand
BDBM50004358
Substrate
n/a
Meas. Tech.
ChEMBL_1336115 (CHEMBL3240943)
IC50
8500±n/a nM
Citation
 Costi, R; Métifiot, M; Chung, S; Cuzzucoli Crucitti, G; Maddali, K; Pescatori, L; Messore, A; Madia, VN; Pupo, G; Scipione, L; Tortorella, S; Di Leva, FS; Cosconati, S; Marinelli, L; Novellino, E; Le Grice, SF; Corona, A; Pommier, Y; Marchand, C; Di Santo, R Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase. J Med Chem 57:3223-34 (2014) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50004358
Synonyms:
CHEMBL3238128
Type:
Small organic molecule
Emp. Form.:
C25H24FN3O5
Mol. Mass.:
465.4736
SMILES:
CN1CCN(CC1)c1ccc2c(c1)n(Cc1ccc(F)cc1)cc(C(=O)\C=C(/O)C(O)=O)c2=O
Structure:
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