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Target
Chromobox protein homolog 8
Ligand
BDBM50009510
Substrate
n/a
Meas. Tech.
ChEMBL_1336413 (CHEMBL3242417)
Kd
1500±n/a nM
Citation
 Simhadri, C; Daze, KD; Douglas, SF; Quon, TT; Dev, A; Gignac, MC; Peng, F; Heller, M; Boulanger, MJ; Wulff, JE; Hof, F Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7). J Med Chem 57:2874-83 (2014) [PubMed]  Article 
Target
Name:
Chromobox protein homolog 8
Synonyms:
CBX8 | CBX8_HUMAN | PC3 | Polycomb 3 homolog | RC1 | Rectachrome 1 | hPc3
Type:
PROTEIN
Mol. Mass.:
43415.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108272
Residue:
389
Sequence:
MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRAREGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGALDPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR
  
Inhibitor
Name:
BDBM50009510
Synonyms:
CHEMBL3234188
Type:
Small organic molecule
Emp. Form.:
C37H55BrN7O7
Mol. Mass.:
789.779
SMILES:
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(N)=O |r|
Structure:
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