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Target
E3 SUMO-protein ligase CBX4
Ligand
BDBM50009454
Substrate
n/a
Meas. Tech.
ChEMBL_1336414 (CHEMBL3242418)
Kd
3700±n/a nM
Citation
 Simhadri, C; Daze, KD; Douglas, SF; Quon, TT; Dev, A; Gignac, MC; Peng, F; Heller, M; Boulanger, MJ; Wulff, JE; Hof, F Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7). J Med Chem 57:2874-83 (2014) [PubMed]  Article 
Target
Name:
E3 SUMO-protein ligase CBX4
Synonyms:
6.3.2.- | CBX4 | CBX4_HUMAN | Chromobox protein homolog 4 | Pc2 | Polycomb 2 homolog | hPc2
Type:
PROTEIN
Mol. Mass.:
61401.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108273
Residue:
560
Sequence:
MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
  
Inhibitor
Name:
BDBM50009454
Synonyms:
CHEMBL3234136
Type:
Small organic molecule
Emp. Form.:
C32H54N7O7
Mol. Mass.:
648.8133
SMILES:
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(N)=O |r|
Structure:
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