Reaction Details
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Report a problem with these dataTarget
Integrase
Ligand
BDBM50011043
Substrate
n/a
Meas. Tech.
ChEMBL_1351355 (CHEMBL3266568)
IC50
350±n/a nM
Citation
Fader, LD; Malenfant, E; Parisien, M; Carson, R; Bilodeau, F; Landry, S; Pesant, M; Brochu, C; Morin, S; Chabot, C; Halmos, T; Bousquet, Y; Bailey, MD; Kawai, SH; Coulombe, R; LaPlante, S; Jakalian, A; Bhardwaj, PK; Wernic, D; Schroeder, P; Amad, M; Edwards, P; Garneau, M; Duan, J; Cordingley, M; Bethell, R; Mason, SW; Bös, M; Bonneau, P; Poupart, MA; Faucher, AM; Simoneau, B; Fenwick, C; Yoakim, C; Tsantrizos, Y Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1. ACS Med Chem Lett 5:422-7 (2014) [PubMed] Article More Info.:
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
Inhibitor
Name:
BDBM50011043
Synonyms:
CHEMBL3259886
Type:
Small organic molecule
Emp. Form.:
C19H16BrNO2
Mol. Mass.:
370.24
SMILES:
Cc1ccc(cc1)-c1c(CC(O)=O)c(C)nc2ccc(Br)cc12
Structure:
