Reaction Details Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM50006215
Substrate
n/a
Meas. Tech.
ChEMBL_1362082 (CHEMBL3294635)
IC50
4125±n/a nM
Citation
Converso, A; Hartingh, T; Fraley, ME; Garbaccio, RM; Hartman, GD; Huang, SY; Majercak, JM; McCampbell, A; Na, SJ; Ray, WJ; Savage, MJ; Wolffe, C; Yeh, S; Yu, Y; White, R; Zhang, R Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase. Bioorg Med Chem Lett 24:2737-40 (2014) [PubMed] Article
More Info.:
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
Inhibitor
Name:
BDBM50006215
Synonyms:
(1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)adenine | (1S,2R,5R)-5-(6-Amino-purin-9-yl)-cyclopent-3-ene-1,2-diol | 5-(6-Amino-purin-9-yl)-cyclopent-3-ene-1,2-diol | CHEMBL299961
Type:
Small organic molecule
Emp. Form.:
C10H11N5O2
Mol. Mass.:
233.2266
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1C=C[C@@H](O)[C@H]1O |c:13|