Reaction Details Report a problem with these data
Target
Bcl-2-like protein 2
Ligand
BDBM50020938
Substrate
n/a
Meas. Tech.
ChEMBL_1365049 (CHEMBL3291805)
Kd
62±n/a nM
Citation
 Koehler, MF; Bergeron, P; Choo, EF; Lau, K; Ndubaku, C; Dudley, D; Gibbons, P; Sleebs, BE; Rye, CS; Nikolakopoulos, G; Bui, C; Kulasegaram, S; Kersten, WJ; Smith, BJ; Czabotar, PE; Colman, PM; Huang, DC; Baell, JB; Watson, KG; Hasvold, L; Tao, ZF; Wang, L; Souers, AJ; Elmore, SW; Flygare, JA; Fairbrother, WJ; Lessene, G Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. ACS Med Chem Lett 5:662-7 (2014) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM50020938
Synonyms:
CHEMBL3287301
Type:
Small organic molecule
Emp. Form.:
C30H26N4O4S2
Mol. Mass.:
570.682
SMILES:
OC(=O)c1nc(sc1CCCOc1ccccc1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1
Structure:
Search PDB for entries with ligand similarity: