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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50046151
Substrate
n/a
Meas. Tech.
ChEMBL_1458165 (CHEMBL3368211)
EC50
183±n/a nM
Citation
 Cheng, MF; Hung, MS; Song, JS; Lin, SY; Liao, FY; Wu, MH; Hsiao, W; Hsieh, CL; Wu, JS; Chao, YS; Shih, C; Wu, SY; Ueng, SH Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors. Bioorg Med Chem Lett 24:3403-6 (2014) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50046151
Synonyms:
CHEMBL3310979
Type:
Small organic molecule
Emp. Form.:
C15H15BrN2O4S
Mol. Mass.:
399.26
SMILES:
OC(=O)CCc1ccc(cc1)S(=O)(=O)NNc1ccc(Br)cc1
Structure:
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