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Target
Histone-lysine N-methyltransferase SETD7
Ligand
BDBM50051117
Substrate
n/a
Meas. Tech.
ChEMBL_1450369 (CHEMBL3378206)
IC50
>100000±n/a nM
Citation
 Ma, A; Yu, W; Li, F; Bleich, RM; Herold, JM; Butler, KV; Norris, JL; Korboukh, V; Tripathy, A; Janzen, WP; Arrowsmith, CH; Frye, SV; Vedadi, M; Brown, PJ; Jin, J Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem 57:6822-33 (2014) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase SETD7
Synonyms:
Histone-lysine N-methyltransferase SETD7 | KIAA1717 | KMT7 | SET domain-containing protein 7/9 (Set7/9) | SET7 | SET9 | SETD7 | SETD7_HUMAN
Type:
Enzyme
Mol. Mass.:
40691.12
Organism:
Homo sapiens (Human)
Description:
Q8WTS6
Residue:
366
Sequence:
MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
  
Inhibitor
Name:
BDBM50051117
Synonyms:
CHEMBL3318285
Type:
Small organic molecule
Emp. Form.:
C23H35N5O2
Mol. Mass.:
413.5563
SMILES:
COc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1
Structure:
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