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Target
Reverse transcriptase
Ligand
BDBM50142734
Substrate
n/a
Meas. Tech.
ChEMBL_1467612 (CHEMBL3411708)
IC50
9600±n/a nM
Citation
 Meleddu, R; Distinto, S; Corona, A; Bianco, G; Cannas, V; Esposito, F; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, F; Tramontano, E; Maccioni, E (3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase. Eur J Med Chem 93:452-60 (2015) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50142734
Synonyms:
(E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dioxo-hex-5-enoic acid ethyl ester | CHEMBL45578
Type:
Small organic molecule
Emp. Form.:
C19H18FNO4
Mol. Mass.:
343.3489
SMILES:
CCOC(=O)C(=O)CC(=O)C=Cc1cccn1Cc1ccc(F)cc1 |w:10.9|
Structure:
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