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Target
Cytochrome P450 3A7 [T409R]
Ligand
BDBM50088503
Substrate
n/a
Meas. Tech.
ChEMBL_1487668 (CHEMBL3532654)
IC50
33000±n/a nM
Citation
 Walsky, RL; Obach, RS; Hyland, R; Kang, P; Zhou, S; West, M; Geoghegan, KF; Helal, CJ; Walker, GS; Goosen, TC; Zientek, MA Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs. Drug Metab Dispos 40:1686-97 (2012) [PubMed]  Article 
Target
Name:
Cytochrome P450 3A7 [T409R]
Synonyms:
CP3A7_HUMAN | CYP3A7 | CYPIIIA7 | Cytochrome P450 3A7 | Cytochrome P450-HFLA
Type:
PROTEIN
Mol. Mass.:
57541.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109496
Residue:
503
Sequence:
MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWREPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
  
Inhibitor
Name:
BDBM50088503
Synonyms:
CHEMBL3527048
Type:
Small organic molecule
Emp. Form.:
C26H32N8
Mol. Mass.:
456.5859
SMILES:
Cc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC[C@@H](C3)N3CCCCC3)c12 |r|
Structure:
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