Reaction Details Report a problem with these data
Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM50109702
Substrate
n/a
Meas. Tech.
ChEMBL_1510006 (CHEMBL3608059)
IC50
24000±n/a nM
Citation
 Pelcman, B; Sanin, A; Nilsson, P; No, K; Schaal, W; Öhrman, S; Krog-Jensen, C; Forsell, P; Hallberg, A; Larhed, M; Boesen, T; Kromann, H; Vogensen, SB; Groth, T; Claesson, HE 3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1. Bioorg Med Chem Lett 25:3024-9 (2015) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
12-LOX | 12/15-lipoxygenase | 15-LOX | Alox12l | Alox15 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, leukocyte-type | Arachidonate omega-6 lipoxygenase | LOX15_RAT
Type:
PROTEIN
Mol. Mass.:
75377.59
Organism:
Rattus norvegicus
Description:
ChEMBL_1510006
Residue:
663
Sequence:
MGVYRIRVSTGDSKYAGSNNEVYLWLVGQHGEASLGKLLRPCRDSEAEFKVDVSEYLGPLLFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQGRSILSLPEGTGCTVVEDSQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISDLPVDQRFREDKRIEFEASQVIGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTPSDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLMAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKAMSTGGGGHLDLLKQAGAFLTYCSLCPPDDLAERGLLDIETCFYAKDALRLWQIMNRYVVGMFNLHYKTDKAVQDDYELQSWCREITDIGLQGAQDRGFPTSLQSRAQACYFITMCIFTCTAQHSSVHLGQLDWFYWVPNAPCTMRLPPPTTKEATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENSVAI
  
Inhibitor
Name:
BDBM50109702
Synonyms:
CHEMBL3604174
Type:
Small organic molecule
Emp. Form.:
C9H6Cl2N4O
Mol. Mass.:
257.076
SMILES:
Clc1ccc(NC(=O)c2cn[nH]n2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: