Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1F
Ligand
BDBM50130461
Substrate
n/a
Meas. Tech.
ChEMBL_1518515 (CHEMBL3618901)
Ki
2.1±n/a nM
Citation
 Zhang, D; Blanco, MJ; Ying, BP; Kohlman, D; Liang, SX; Victor, F; Chen, Q; Krushinski, J; Filla, SA; Hudziak, KJ; Mathes, BM; Cohen, MP; Zacherl, D; Nelson, DL; Wainscott, DB; Nutter, SE; Gough, WH; Schaus, JM; Xu, YC Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT1 F receptor agonists: Evolution from bicyclic to monocyclic cores. Bioorg Med Chem Lett 25:4337-41 (2015) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1F
Synonyms:
5-HT-1F | 5-HT1F | 5-hydroxytryptamine receptor 1F | 5HT1F_HUMAN | HTR1EL | HTR1F | Serotonin (5-HT) receptor | Serotonin 1f (5-HT1f) receptor | Serotonin receptor 1F
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41724.68
Organism:
Homo sapiens (Human)
Description:
5-HT1F HTR1F HUMAN::P30939
Residue:
366
Sequence:
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
  
Inhibitor
Name:
BDBM50130461
Synonyms:
4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide | 4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-5-yl]-benzamide | CHEMBL101690 | LY-334370
Type:
Small organic molecule
Emp. Form.:
C21H22FN3O
Mol. Mass.:
351.4173
SMILES:
CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Structure:
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