Target
Aurora kinase B
Ligand
BDBM50135130
Substrate
n/a
Meas. Tech.
ChEMBL_1545255 (CHEMBL3751005)
IC50
132±n/a nM
Citation
 Vasbinder, MMAlimzhanov, MAugustin, MBebernitz, GBell, KChuaqui, CDeegan, TFerguson, ADGoodwin, KHuszar, DKawatkar, AKawatkar, SRead, JShi, JSteinbacher, SSteuber, HSu, QToader, DWang, HWoessner, RWu, AYe, MZinda, M Identification of azabenzimidazoles as potent JAK1 selective inhibitors. Bioorg Med Chem Lett 26:60-7 (2015) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50135130
Synonyms:
CHEMBL3746463
Type:
Small organic molecule
Emp. Form.:
C20H23ClFN5O2
Mol. Mass.:
419.88
SMILES:
COc1cc(F)c(cc1OC)-c1nc2c(NCC3CCNCC3)c(Cl)cnc2[nH]1
Structure:
Search PDB for entries with ligand similarity: