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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50138827
Substrate
n/a
Meas. Tech.
ChEMBL_1547128 (CHEMBL3755863)
IC50
<1000±n/a nM
Citation
 Peng, YH; Ueng, SH; Tseng, CT; Hung, MS; Song, JS; Wu, JS; Liao, FY; Fan, YS; Wu, MH; Hsiao, WC; Hsueh, CC; Lin, SY; Cheng, CY; Tu, CH; Lee, LC; Cheng, MF; Shia, KS; Shih, C; Wu, SY Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1. J Med Chem 59:282-93 (2016) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50138827
Synonyms:
CHEMBL3752711 | US10233190, Example 1418
Type:
Small organic molecule
Emp. Form.:
C18H22N2O
Mol. Mass.:
282.3801
SMILES:
O[C@H](C[C@H]1c2ccccc2-c2cncn12)C1CCCCC1 |r|
Structure:
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