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Target
Actin nucleation-promoting factor WASL
Ligand
BDBM50154293
Substrate
n/a
Meas. Tech.
ChEMBL_1561127 (CHEMBL3777062)
IC50
3440±n/a nM
Citation
 Pfeffer, TJ; Sasse, F; Schmidt, CF; Lakämper, S; Kirschning, A; Scholz, T The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function. Eur J Med Chem 112:164-70 (2016) [PubMed]  Article 
Target
Name:
Actin nucleation-promoting factor WASL
Synonyms:
N-WASP | Neural Wiskott-Aldrich syndrome protein | WASL_RAT | Wasl
Type:
PROTEIN
Mol. Mass.:
54331.18
Organism:
Rattus norvegicus
Description:
ChEMBL_116750
Residue:
501
Sequence:
MSSGQQPPRRVTNVGSLLLTPQENESLFSFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDAPNGPNLPMATVDIKNPEITTNRFYSSQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHSSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPGVVVPPPPPNRMYPPPPPALPSSAPSGPPPPPPLSMAGSTAPPPPPPPPPPPGPPPPPGLPSDGDHQVPASSGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVSDGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDDDDEEDFQDDDEWED
  
Inhibitor
Name:
BDBM50154293
Synonyms:
CHEMBL3774960
Type:
Small organic molecule
Emp. Form.:
C17H18Br2N2O
Mol. Mass.:
426.146
SMILES:
CN(C)C[C@@H](O)Cn1c2ccc(Br)cc2c2cc(Br)ccc12 |r|
Structure:
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