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Target
Carboxypeptidase B2
Ligand
BDBM50197573
Substrate
n/a
Meas. Tech.
ChEMBL_1619504 (CHEMBL3861673)
IC50
3±n/a nM
Citation
 Halland, N; Czech, J; Czechtizky, W; Evers, A; Follmann, M; Kohlmann, M; Schreuder, HA; Kallus, C Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J Med Chem 59:9567-9573 (2016) [PubMed]  Article 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM50197573
Synonyms:
CHEMBL3912764
Type:
Small organic molecule
Emp. Form.:
C26H46N4O4
Mol. Mass.:
478.6678
SMILES:
CC1(C)C2CCC1(C)[C@H](C2)NC(=O)[C@H](CC1CCCCC1)NC(=O)N[C@@H](CCCCN)C(O)=O |r,THB:10:8:4.5:1|
Structure:
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