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Target
Cytoplasmic tyrosine-protein kinase BMX
Ligand
BDBM50236045
Substrate
n/a
Meas. Tech.
ChEMBL_1658703 (CHEMBL4008315)
IC50
>10000±n/a nM
Citation
 Liang, X; Lv, F; Wang, B; Yu, K; Wu, H; Qi, Z; Jiang, Z; Chen, C; Wang, A; Miao, W; Wang, W; Hu, Z; Liu, J; Liu, X; Zhao, Z; Wang, L; Zhang, S; Ye, Z; Wang, C; Ren, T; Wang, Y; Liu, Q; Liu, J Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor. J Med Chem 60:1793-1816 (2017) [PubMed]  Article 
Target
Name:
Cytoplasmic tyrosine-protein kinase BMX
Synonyms:
BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK
Type:
Tyrosine-protein kinase
Mol. Mass.:
78030.42
Organism:
Homo sapiens (Human)
Description:
P51813
Residue:
675
Sequence:
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH
  
Inhibitor
Name:
BDBM50236045
Synonyms:
CHEMBL4086774
Type:
Small organic molecule
Emp. Form.:
C34H41N7O3
Mol. Mass.:
595.7344
SMILES:
CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccc(C)c(c1)N1Cc2cnc(Nc3ccc(C)c(NC(=O)C=C)c3)nc2N(C)C1=O |r,wU:6.9,wD:3.2,(66.11,-20.74,;64.78,-21.51,;64.78,-23.04,;63.45,-20.74,;63.46,-19.2,;62.12,-18.42,;60.8,-19.2,;60.8,-20.73,;62.12,-21.5,;59.47,-18.44,;59.47,-16.89,;58.14,-19.21,;56.8,-18.44,;56.79,-16.89,;55.45,-16.12,;54.12,-16.89,;52.78,-16.12,;54.12,-18.44,;55.46,-19.21,;52.78,-19.21,;51.45,-18.43,;50.13,-19.2,;48.81,-18.42,;47.47,-19.17,;47.46,-20.72,;46.12,-21.49,;46.11,-23.03,;44.77,-23.78,;44.76,-25.32,;46.09,-26.11,;46.08,-27.65,;47.44,-25.33,;48.77,-26.11,;50.11,-25.33,;50.11,-23.79,;51.44,-26.11,;51.42,-27.65,;47.44,-23.79,;48.79,-21.49,;50.12,-20.73,;51.45,-21.51,;51.44,-23.06,;52.79,-20.74,;54.13,-21.52,)|
Structure:
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