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Found 2787 with Last Name = 'ren' and Initial = 't'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283355(CHEMBL311418 | {(S)-1-[3-(Benzyl-methyl-carbamoyl)...)
Affinity DataKi:  0.400nMAssay Description:Compound was tested for inactivation of purified HIV-1 protease in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283358(CHEMBL79799 | [(S)-1-(1-Benzyl-3-benzylcarbamoyl-3...)
Affinity DataKi:  1nMAssay Description:Compound was tested for inactivation of purified HIV-1 protease in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50031306(8-chlorospiro[1,2,3,4-tetrahydronaphthalene-2,4'-(...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University Of Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM400813(QL-X-138 | US10000483, Compound II-6)
Affinity DataKi:  2nMAssay Description:Irreversible inhibition of recombinant full length His-tagged human BTK expressed in baculovirus expression system using poly (4:1 Glu, Tyr) as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50031324(5',7'-dichlorospiro[4,5-dihydro-1H-imidazole-4,2'-...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University Of Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM102620(BMX-IN-1 | N-[5-[9-[4-(methanesulfonamido)phenyl]-...)
Affinity DataKi:  3.20nMAssay Description:Irreversible inhibition of recombinant full length His-tagged human BTK expressed in baculovirus expression system using poly (4:1 Glu, Tyr) as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50286092(3-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-1H-in...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT radioligand assay.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50286098(3-(1-Propyl-1,2,5,6-tetrahydro-pyridin-3-yl)-1H-in...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT radioligand assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University Of Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataKi:  4.80nMAssay Description:Reversible inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,T...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50202986(2-furan-2-yl-7-(2-{4-[4-(2-methoxy-ethoxy)-phenyl]...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in buculovirus system by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50037811(CHEMBL123016 | {(S)-1-[(S)-3-Benzylcarbamoyl-1-(4-...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity of the compound was determined against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2a(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50202986(2-furan-2-yl-7-(2-{4-[4-(2-methoxy-ethoxy)-phenyl]...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in high five cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50037811(CHEMBL123016 | {(S)-1-[(S)-3-Benzylcarbamoyl-1-(4-...)
Affinity DataKi:  5nMAssay Description:Compound was tested for inactivation of purified HIV-1 protease in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283362(CHEMBL311049 | {(S)-1-[1-(4-Benzyloxy-benzyl)-3,3-...)
Affinity DataKi:  5nMAssay Description:Compound was tested for inactivation of purified HIV-1 protease in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50422013(LOBELINE | Lobeline Hydrochloride)
Affinity DataKi:  5nMAssay Description:Binding affinity to alpha4beta2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50422013(LOBELINE | Lobeline Hydrochloride)
Affinity DataKi:  5nMAssay Description:Binding affinity to alpha4beta2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50231651(CHEMBL283398)
Affinity DataKi:  5.30nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50286073(5-Methoxy-3-(1,2,5,6-tetrahydro-pyridin-3-yl)-1H-i...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT radioligand assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2a(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50336715(4-(3,3-Dimethyl-butyrylamino)-3,5-difluoro-N-thiaz...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in high five cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University Of Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50245603(CHEMBL4096207)
Affinity DataKi:  6nMAssay Description:Reversible inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50031311(7'-methylspiro[4,5-dihydro-1H-imidazole-4,2'-(1',2...)
Affinity DataKi:  7nMAssay Description:Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50282534(CHEMBL21095 | {(S)-1-[1-(4-Benzyloxy-benzyl)-3-((R...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity of the compound was determined against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University Of Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataKi:  8.90nMAssay Description:Reversible inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,T...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50428509(CHEMBL2331608)
Affinity DataKi:  8.90nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 10 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50428503(CHEMBL2336615)
Affinity DataKi:  9.10nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 10 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50336712(4-(3,3-Dimethyl-butyrylamino)-3-fluoro-N-thiazol-2...)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in high five cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50428512(CHEMBL2336626)
Affinity DataKi:  9.60nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 10 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM81498(5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-i...)
Affinity DataKi:  11nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT radioligand assay.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM81498(5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-i...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50209178(5-Bromo-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-y...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  12nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 10 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50324983(CHEMBL1221457 | Cyclopropanecarboxylic acid[5-(3-m...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in buculovirus system by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50336719(4-(3,3-Dimethyl-butyrylamino)-5-fluoro-2-methoxy-N...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in high five cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50031316(5'-methoxyspiro[4,5-dihydro-1H-imidazole-4,2'-(1',...)
Affinity DataKi:  12nMAssay Description:Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50031301(8'-fluorospiro[4,5-dihydro-1H-imidazole-4,2'-(1',2...)
Affinity DataKi:  12nMAssay Description:Binding affinity towards Alpha-2A adrenergic receptor in human platelets using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50324967(2-[(Furan-2-carbonyl)-amino]-4-phenyl-thiazole-5-c...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in buculovirus system by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50428520(CHEMBL2336632)
Affinity DataKi:  13nMAssay Description:Inhibition of human carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University Of Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50245587(CHEMBL4077064 | US10000483, Compound II-4)
Affinity DataKi:  14nMAssay Description:Irreversible inhibition of recombinant full length His-tagged human BTK expressed in baculovirus expression system using poly (4:1 Glu, Tyr) as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University Of Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50245587(CHEMBL4077064 | US10000483, Compound II-4)
Affinity DataKi:  14nMAssay Description:Reversible inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
University Of Georgia

Curated by ChEMBL
LigandPNGBDBM50158037(1-Benzyl-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-...)
Affinity DataKi:  15nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]-ketanserin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50428518(CHEMBL2336620)
Affinity DataKi:  15nMAssay Description:Inhibition of human carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50286089(CHEMBL100814 | N-[3-(1-Methyl-1,2,5,6-tetrahydro-p...)
Affinity DataKi:  16nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT radioligand assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50428512(CHEMBL2336626)
Affinity DataKi:  17nMAssay Description:Inhibition of human carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50336717(4-(3,3-Dimethyl-butyrylamino)-3-methoxy-N-thiazol-...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in high five cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50231649(CHEMBL281432)
Affinity DataKi:  17nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50428501(CHEMBL2336617)
Affinity DataKi:  19nMAssay Description:Inhibition of human carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50428511(CHEMBL2336627)
Affinity DataKi:  19nMAssay Description:Inhibition of human carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50336714(4-(3,3-Dimethyl-butyrylamino)-3-methyl-N-thiazol-2...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in high five cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
University Of Georgia

Curated by ChEMBL
LigandPNGBDBM50231652(CHEMBL341485)
Affinity DataKi:  19nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]-ketanserin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50231634(CHEMBL27643)
Affinity DataKi:  19nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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