Reaction Details Report a problem with these data
Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM50238113
Substrate
n/a
Meas. Tech.
ChEBML_1662801
IC50
5100±n/a nM
Citation
 Meguro, M; Miyauchi, S; Kanao, Y; Naito, S; Suzuki, K; Inoue, S; Yamada, K; Homma, T; Chiba, K; Nara, F; Furuzono, S 4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures. Bioorg Med Chem Lett 27:1902-1906 (2017) [PubMed]  Article 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone synthase | C11B2_MOUSE | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B2, mitochondrial | Cytochrome P450C11 | Steroid 11-beta-hydroxylase
Type:
PROTEIN
Mol. Mass.:
57397.51
Organism:
Mus musculus
Description:
ChEMBL_109884
Residue:
500
Sequence:
MALRVTADVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQVFRELGPIFRHSVGKTQIVSVMLPEDAEKLHQVESMLPRRMHLEPWVAHRELRGLRRGVFLLNGPEWRLNRLRLNRNVLSPKAVQKFVPMVDMVARDFLETLKEKVLQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLSPGSLKFIHALHSMFKSTSQLLFLPKSLTRWTSTRVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAELISQGSLPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQKALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILSSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMMLLLHHILKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPVS
  
Inhibitor
Name:
BDBM50238113
Synonyms:
CHEMBL4067686
Type:
Small organic molecule
Emp. Form.:
C17H19FN4O3S
Mol. Mass.:
378.421
SMILES:
CS(=O)(=O)N1CCC(CC1)C(=O)c1cncnc1Nc1ccc(F)cc1
Structure:
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