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Target
Glutaminase liver isoform, mitochondrial
Ligand
BDBM50238203
Substrate
n/a
Meas. Tech.
ChEMBL_1663489 (CHEMBL4013170)
IC50
4188±n/a nM
Citation
 Yeh, TK; Kuo, CC; Lee, YZ; Ke, YY; Chu, KF; Hsu, HY; Chang, HY; Liu, YW; Song, JS; Yang, CW; Lin, LM; Sun, M; Wu, SH; Kuo, PC; Shih, C; Chen, CT; Tsou, LK; Lee, SJ Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors. J Med Chem 60:5599-5612 (2017) [PubMed]  Article 
Target
Name:
Glutaminase liver isoform, mitochondrial
Synonyms:
3.5.1.2 | GA | GLS | GLS2 | GLSL_HUMAN | Glutaminase liver isoform, mitochondrial | L-glutaminase | L-glutamine amidohydrolase
Type:
PROTEIN
Mol. Mass.:
66331.64
Organism:
Homo sapiens
Description:
ChEMBL_117753
Residue:
602
Sequence:
MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV
  
Inhibitor
Name:
BDBM50238203
Synonyms:
CHEMBL4074218
Type:
Small organic molecule
Emp. Form.:
C26H18ClN3O4S2
Mol. Mass.:
536.022
SMILES:
Cc1cc(\C=C2/SC(=O)NC2=O)c(C)n1-c1ccc(cc1)-c1ccc(\C=C2/SC(=O)NC2=O)c(Cl)c1
Structure:
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