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Target
Homoserine kinase
Ligand
BDBM85124
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±0
Temperature
310.15±0 K
Ki
4.6e+2± 4e+1 nM
Citation
 De Pascale, G; Griffiths, EJ; Shakya, T; Nazi, I; Wright, GD Identification and characterization of new inhibitors of fungal homoserine kinase. Chembiochem 12:1179-82 (2011) [PubMed]  Article 
Target
Name:
Homoserine kinase
Synonyms:
KHSE_ECOLI | thrB
Type:
Enzyme
Mol. Mass.:
33619.26
Organism:
Escherichia coli
Description:
P00547
Residue:
310
Sequence:
MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPETAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
  
Inhibitor
Name:
BDBM85124
Synonyms:
Thr1 inhibitor, 4
Type:
Small organic molecule
Emp. Form.:
C19H14O6
Mol. Mass.:
338.3109
SMILES:
Oc1c(CC2C(=O)OC3C=CCC=C3C2=O)c(=O)oc2ccccc12 |c:9,12|
Structure:
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