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Target
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
Ligand
BDBM85276
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
8±0
Temperature
310.15±0 K
IC50
5.7e+4±n/a nM
Citation
 Sova, M; Kovac, A; Turk, S; Hrast, M; Blanot, D; Gobec, S Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF. Bioorg Chem 37:217-22 (2009) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
Synonyms:
MURE_STAA8 | MurE (S. aureus) | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | murE
Type:
Protein
Mol. Mass.:
54095.36
Organism:
Staphylococcus aureus
Description:
Q2FZP6
Residue:
493
Sequence:
MDASTLFKKVKVKRVLGSLEQQIDDITTDSRTAREGSIFVASVGYTVDSHKFCQNVADQGCKLVVVNKEQSLPANVTQVVVPDTLRVASILAHTLYDYPSHQLVTFGVTGTNGKTSIATMIHLIQRKLQKNSAYLGTNGFQINETKTKGANTTPETVSLTKKIKEAVDAGAESMTLEVSSHGLVLGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLSKEKYVVLNNDDSFSEYLRTVTPYEVFSYGIDEEAQFMAKNIQESLQGVSFDFVTPFGTYPVKSPYVGKFNISNIMAAMIAVWSKGTSLETIIKAVENLEPVEGRLEVLDPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGERDLTKTPEMGRVACRADYVIFTPDNPANDDPKMLTAELAKGATHQNYIEFDDRAEGIKHAIDIAEPGDTVVLASKGREPYQIMPGHIKVPHRDDLIGLEAAYKKFGGGPVD
  
Inhibitor
Name:
BDBM85276
Synonyms:
HEA derivative, 7c | MurC/D/E/F inhibitor (compound 68)
Type:
Small organic molecule
Emp. Form.:
C14H20F3N2O7PS
Mol. Mass.:
448.352
SMILES:
OP(O)(=O)OC(CNS(=O)(=O)c1ccc(cc1)C(F)(F)F)CN1CCOCC1
Structure:
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