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Target
Thromboxane A2 receptor
Ligand
BDBM50167939
Substrate
n/a
Ki
3.1±n/a nM
Comments
PDSP_4502
Citation
 Hanson, J; Rolin, S; Reynaud, D; Qiao, N; Kelley, LP; Reid, HM; Valentin, F; Tippins, J; Kinsella, BT; Masereel, B; Pace-Asciak, C; Pirotte, B; Dogné, JM In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist. J Pharmacol Exp Ther 313:293-301 (2005) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50167939
Synonyms:
3,4-DNH | 5-Hydroxy Tryptamine | BM 613 | Benzen | Benzine | Benzol | Bicarburet of hydrogen | CHEMBL277500 | Cc-34,(+/-) | Coal naphtha | Mineral naphtha | Phene | Pyrobenzol | Pyrobenzole | [6]annulene | benzene | benzole | cyclohexatriene | erythro-Phenyl-2-piperidyl-carbinol,(-) | phenyl hydride | trans-N, N-Dimethylphenylcyclopropylamine | trans-N-Methylphenylcyclopropylamine
Type:
Small organic molecule
Emp. Form.:
C6H6
Mol. Mass.:
78.1118
SMILES:
c1ccccc1
Structure:
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