Reaction Details Report a problem with these data
Target
cGMP-dependent protein kinase 1
Ligand
BDBM14027
Substrate
n/a
Ki
1600±n/a nM
Comments
PDSP_6133
Citation
 Braverman, AS; Tibb, AS; Ruggieri, MR M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder. J Pharmacol Exp Ther 316:869-74 (2006) [PubMed]  Article 
Target
Name:
cGMP-dependent protein kinase 1
Synonyms:
GMP-dependent protein kinase I | cGMP-dependent protein kinase 1 | Protein Kinase G | cGMP-dependent protein kinase 1 beta | cGMP-dependent protein kinase | KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B
Type:
Protein
Mol. Mass.:
76358.04
Organism:
Human
Description:
Q13976
Residue:
671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
  
Inhibitor
Name:
BDBM14027
Synonyms:
AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4-diazepane-1-sulfonyl)isoquinoline | CHEMBL541388 | HA-1077 | cid_163751 | Fasudil (HA-1077) | US9687483, Fasudil | US20240246972, Compound Fasudil
Type:
Small organic molecule
Emp. Form.:
C14H17N3O2S
Mol. Mass.:
291.10
SMILES:
c1cc2cnccc2c(c1)S(=O)(=O)N3CCCNCC3
Structure:
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