BDBM14027 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline::5-(1,4-diazepane-1-sulfonyl)isoquinoline::AT877::CHEMBL38380::CHEMBL541388::Fasudil (HA-1077)::HA-1077::US9687483, Fasudil::cid_163751
SMILES O=S(=O)(N1CCCNCC1)c1cccc2cnccc12
InChI Key InChIKey=NGOGFTYYXHNFQH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 72 hits for monomerid = 14027
TargetRho-associated protein kinase 2(Rattus norvegicus (Rat))
Temple University
Curated by PDSP Ki Database
Temple University
Curated by PDSP Ki Database
Affinity DataKi: 330nMAssay Description:Inhibition of ROCK (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals
Vertex Pharmaceuticals
Affinity DataKi: 460nM ΔG°: -8.78kcal/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
Affinity DataKi: 530nMAssay Description:Inhibition of human leukocytic ROCK1 expressed in insect cells using KKRNRTLSV as substrate after 10 mins by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
Affinity DataKi: 530nM ΔG°: -8.70kcal/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Temple University
Curated by PDSP Ki Database
Temple University
Curated by PDSP Ki Database
TargetcAMP-dependent protein kinase catalytic subunit beta(RAT)
Temple University
Curated by PDSP Ki Database
Temple University
Curated by PDSP Ki Database
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd
Curated by ChEMBL
Msd
Curated by ChEMBL
Affinity DataKi: 2.51E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of ROCK-2 by Immobilized metal ion affinity-based fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.92E+3nMAssay Description:Inhibition of MCP1-mediated human THP cell migrationMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 1.49E+3nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 893nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [V123M](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 7.61E+3nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [T183A](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 607nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [E127D](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 2.45E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 541nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [V123M,T183A](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 1.35E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 870nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [V123M,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 1.95E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 1.13E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,E127D,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center
German Cancer Research Center
Affinity DataIC50: 2.28E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
Affinity DataIC50: 485nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 853nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 33(Homo sapiens (Human))
Broad Institute
Curated by PubChem BioAssay
Broad Institute
Curated by PubChem BioAssay
Affinity DataEC50: 9.58E+3nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Rattus norvegicus (Rat))
Temple University
Curated by PDSP Ki Database
Temple University
Curated by PDSP Ki Database
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of rat ROCK2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 78nMAssay Description:Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre Of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 2.16E+4nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetMyotonin-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of DMPKMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of MCP1-induced chemotaxis in U937 cells overexpressing CCR2More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of PrkceMore data for this Ligand-Target Pair
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of CDc42More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of His-tagged human PRK2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of His-tagged human MSK1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Protein kinase ROCK2 (ROCKII)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Protein kinase C related kinase 1 (PRK1)More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of MCP1-induced cell migration in U937 cells expressing CCR2 by chemotaxis assayMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
TargetMO15-related protein kinase Pfmrk(Plasmodium falciparum)
Institute Of Research
Curated by ChEMBL
Institute Of Research
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of Plasmodium falciparum PfmrkMore data for this Ligand-Target Pair
Affinity DataIC50: 158nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair