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Target
Delta-type opioid receptor
Ligand
BDBM78178
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>92447±n/a nM
Citation
 PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM78178
Synonyms:
3-[2-(3-Hydroxy-phenylamino)-thiazol-4-yl]-6-methoxy-chromen-2-one | 3-[2-(3-hydroxyanilino)-1,3-thiazol-4-yl]-6-methoxychromen-2-one | 3-[2-(3-hydroxyanilino)-4-thiazolyl]-6-methoxy-1-benzopyran-2-one | 3-[2-(3-hydroxyanilino)thiazol-4-yl]-6-methoxy-coumarin | 3-[2-[(3-hydroxyphenyl)amino]-1,3-thiazol-4-yl]-6-methoxy-chromen-2-one | MLS000548677 | SMR000172285 | cid_1077600
Type:
Small organic molecule
Emp. Form.:
C19H14N2O4S
Mol. Mass.:
366.39
SMILES:
COc1ccc2oc(=O)c(cc2c1)-c1csc(Nc2cccc(O)c2)n1
Structure:
Search PDB for entries with ligand similarity: