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Target
RNA-directed RNA polymerase
Ligand
BDBM100759
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
10±n/a nM
Citation
 Yeung, K; Kadow, JF; Bora, RO; Selvakumar, K Compounds for the treatment of hepatitis C US Patent  US8507683 Publication Date 8/13/2013 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM100759
Synonyms:
US8507683, 10
Type:
Small organic molecule
Emp. Form.:
C31H24F2N4O4
Mol. Mass.:
554.5435
SMILES:
CNC(=O)c1c(oc2ccc(c(F)c12)-c1cc(ccc1C)C(=O)NC1(COC1)c1ncccn1)-c1ccc(F)cc1
Structure:
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