Reaction Details Report a problem with these data
Target
Alpha-galactosidase A
Ligand
BDBM113759
Substrate
n/a
Meas. Tech.
α-Gal A Assay
pH
5.0000±0.0000
IC50
3.4e+2± 47 nM
Citation
 Yu, Y; Mena-Barragán, T; Mena-Barragán, K; Johnson, JL; Drury, JE; Lieberman, RL; Nakasone, N; Ninomiya, H; Tsukimura, T; Sakuraba, H; Suzuki, Y; Nanba, E; Mellet, CO; García Fernández, JM; García Fernández, K Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human a-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants. ACS Chem Biol 9:1460-9 (2014) [PubMed]  Article 
Target
Name:
Alpha-galactosidase A
Synonyms:
INN=Agalsidase | Melibiase | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | AGAL_HUMAN | GLA | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A)
Type:
Protein
Mol. Mass.:
48760.21
Organism:
Human
Description:
n/a
Residue:
429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
  
Inhibitor
Name:
BDBM113759
Synonyms:
DGJ-pF PhT
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1cc(ccc1NC(=S)N2C[C@@H]([C@H]([C@H]([C@H]2CO)O)O)O)F
Structure:
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