Reaction Details Report a problem with these data
Target
Alpha-galactosidase A
Ligand
BDBM113762
Substrate
n/a
Meas. Tech.
α-Gal A Assay
pH
7.0000±0.0000
IC50
0.78± 0.13 nM
Citation
 Yu, Y; Mena-Barragán, T; Mena-Barragán, K; Johnson, JL; Drury, JE; Lieberman, RL; Nakasone, N; Ninomiya, H; Tsukimura, T; Sakuraba, H; Suzuki, Y; Nanba, E; Mellet, CO; García Fernández, JM; García Fernández, K Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human a-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants. ACS Chem Biol 9:1460-9 (2014) [PubMed]  Article 
Target
Name:
Alpha-galactosidase A
Synonyms:
INN=Agalsidase | Melibiase | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | AGAL_HUMAN | GLA | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A)
Type:
Protein
Mol. Mass.:
48760.21
Organism:
Human
Description:
n/a
Residue:
429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
  
Inhibitor
Name:
BDBM113762
Synonyms:
2-(hydroxymethyl)piperidine-3,4,5-triol;hydrochloride | 1-Deoxygalactonojirimycin (DGJ)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: