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Target
UDP-N-acetylmuramate--L-alanine ligase
Ligand
BDBM123102
Substrate
n/a
Meas. Tech.
P. aeruginosa MurC assay
Temperature
298.15±0 K
IC50
1.0e+3±n/a nM
Citation
 Hameed P, S; Manjrekar, P; Chinnapattu, M; Humnabadkar, V; Shanbhag, G; Kedari, C; Mudugal, NV; Ambady, A; de Jonge, BL; Sadler, C; Paul, B; Sriram, S; Kaur, P; Guptha, S; Raichurkar, A; Fleming, P; Eyermann, CJ; McKinney, DC; Sambandamurthy, VK; Panda, M; Ravishankar, S Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli. ACS Chem Biol 9:2274-82 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramate--L-alanine ligase
Synonyms:
MURC_PSEAE | MurC (P. aeruginosa) | murC
Type:
Protein
Mol. Mass.:
51977.96
Organism:
Pseudomonas aeruginosa (G-proteobacteria)
Description:
Q9HW02
Residue:
480
Sequence:
MVKEPNGVTRTMRRIRRIHFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFGAQIFIGHQAENADGADVLVVSSAINRANPEVASALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGASRYLVAEADESDASFLHLQPMVAVVTNIDADHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCVDDPVVREILPQIARPTVTYGLSEDADVRAINIRQEGMRTWFTVLRPEREPLDVSVNMPGLHNVLNSLATIVIATDEGISDEAIVQGLSGFQGVGRRFQVYGELQVEGGSVMLVDDYGHHPREVAAVIKAIRGGWPERRLVMVYQPHRYTRTRDLYEDFVQVLGEANVLLLMEVYPAGEEPIPGADSRQLCHSIRQRGQLDPIYFERDADLAPLVKPLLRAGDILLCQGAGDVGGLAPQLIKNPLFAGKGGKGA
  
Inhibitor
Name:
BDBM123102
Synonyms:
(1-(4-(3-cyclopropyl-1H-pyrazol-5-ylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidin-2-yl)methanol (1)
Type:
Small organic molecule
Emp. Form.:
C17H22N8O
Mol. Mass.:
354.4096
SMILES:
OCC1CCCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2c[nH]nc2n1
Structure:
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