Reaction Details Report a problem with these data
Target
UDP-N-acetylmuramate--L-alanine ligase
Ligand
BDBM123126
Substrate
n/a
Meas. Tech.
P. aeruginosa MurC assay
Temperature
298.15±0 K
IC50
7±n/a nM
Citation
Hameed P, S; Manjrekar, P; Chinnapattu, M; Humnabadkar, V; Shanbhag, G; Kedari, C; Mudugal, NV; Ambady, A; de Jonge, BL; Sadler, C; Paul, B; Sriram, S; Kaur, P; Guptha, S; Raichurkar, A; Fleming, P; Eyermann, CJ; McKinney, DC; Sambandamurthy, VK; Panda, M; Ravishankar, S Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli. ACS Chem Biol 9:2274-82 (2014) [PubMed] Article
More Info.:
Target
Name:
UDP-N-acetylmuramate--L-alanine ligase
Synonyms:
MURC_PSEAE | MurC (P. aeruginosa) | murC
Type:
Protein
Mol. Mass.:
51977.96
Organism:
Pseudomonas aeruginosa (G-proteobacteria)
Description:
Q9HW02
Residue:
480
Sequence:
MVKEPNGVTRTMRRIRRIHFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFGAQIFIGHQAENADGADVLVVSSAINRANPEVASALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGASRYLVAEADESDASFLHLQPMVAVVTNIDADHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCVDDPVVREILPQIARPTVTYGLSEDADVRAINIRQEGMRTWFTVLRPEREPLDVSVNMPGLHNVLNSLATIVIATDEGISDEAIVQGLSGFQGVGRRFQVYGELQVEGGSVMLVDDYGHHPREVAAVIKAIRGGWPERRLVMVYQPHRYTRTRDLYEDFVQVLGEANVLLLMEVYPAGEEPIPGADSRQLCHSIRQRGQLDPIYFERDADLAPLVKPLLRAGDILLCQGAGDVGGLAPQLIKNPLFAGKGGKGA
Inhibitor
Name:
BDBM123126
Synonyms:
(R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-2-phenylethyl 2-(3-oxopyrazolidin-1-yl)ethylcarbamate (25)
Type:
Small organic molecule
Emp. Form.:
C27H35N11O3
Mol. Mass.:
561.6387
SMILES:
Cn1nc(Nc2nc(N[C@@H](COC(=O)NCCN3CCC(=O)N3)c3ccccc3)nc3n[nH]cc23)cc1C(C)(C)C