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Target
UDP-N-acetylmuramate--L-alanine ligase
Ligand
BDBM123119
Substrate
n/a
Meas. Tech.
E.coli MurC assay
Temperature
298.15±0 K
IC50
15±n/a nM
Citation
 Hameed P, S; Manjrekar, P; Chinnapattu, M; Humnabadkar, V; Shanbhag, G; Kedari, C; Mudugal, NV; Ambady, A; de Jonge, BL; Sadler, C; Paul, B; Sriram, S; Kaur, P; Guptha, S; Raichurkar, A; Fleming, P; Eyermann, CJ; McKinney, DC; Sambandamurthy, VK; Panda, M; Ravishankar, S Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli. ACS Chem Biol 9:2274-82 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramate--L-alanine ligase
Synonyms:
MURC_ECOLI | MurC (E. coli) | UDP-N-acetylmuramate--L-alanine ligase | murC
Type:
Protein
Mol. Mass.:
53617.78
Organism:
Escherichia coli
Description:
P17952
Residue:
491
Sequence:
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLMNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPARVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKLKPQTPEEEQHD
  
Inhibitor
Name:
BDBM123119
Synonyms:
(R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-2-(2-methoxypyridin-4-yl)ethanol (18)
Type:
Small organic molecule
Emp. Form.:
C21H27N9O2
Mol. Mass.:
437.4982
SMILES:
COc1cc(ccn1)[C@H](CO)Nc1nc(Nc2cc(n(C)n2)C(C)(C)C)c2c[nH]nc2n1
Structure:
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