Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM144345
Substrate
n/a
Meas. Tech.
In Vitro Assay
pH
8±n/a
IC50
360±n/a nM
Comments
extracted
Citation
 Abeywardane, A; Hao, M; Taylor, SJ Chymase inhibitors US Patent  US8969348 Publication Date 3/3/2015 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM144345
Synonyms:
US8969348, {4-[(1-Methyl-1H-indol-3-yl)methyl]-1-oxophthalazin-2(1H)-yl}(phenyl)acetic acid
Type:
Small organic molecule
Emp. Form.:
C26H21N3O3
Mol. Mass.:
423.4632
SMILES:
Cn1cc(Cc2nn(C(C(O)=O)c3ccccc3)c(=O)c3ccccc23)c2ccccc12
Structure:
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