Reaction Details Report a problem with these data
Target
Endothelial lipase
Ligand
BDBM147472
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
310.15±n/a K
IC50
32±n/a nM
Comments
extracted
Citation
 Masuda, K; Kida, S; Hayashi, K; Katou, M; Yoshikawa, N; Kugimiya, A; Nakajima, M; Tanaka, N Acetic acid amide derivative having inhibitory activity on endothelial lipase US Patent  US8957219 Publication Date 2/17/2015 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM147472
Synonyms:
US8957219, II-2-211
Type:
Small organic molecule
Emp. Form.:
C20H17N3O2S
Mol. Mass.:
363.433
SMILES:
O=C(CNC(=O)Cc1nc2ccc(cc2s1)-c1ccccc1)NCC#C
Structure:
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